Article
Aberrant caspase-activated DNase (CAD) transcripts in human hepatoma cells.
British journal of cancer - 27 Jan 2003
Hsieh S Y, Liaw S F, Lee S N, Hsieh P S, Lin K H, Chu C M, Liaw Y F
Abstract excerpt
The gene of caspase-activated DNase (CAD), the key enzyme for nucleosome cleavage during apoptosis, is mapped at chromosome 1p36, a region usually associated with hemizygous deletions in human cancers, particularly in hepatoma (HCC). It is tempting to speculate that CAD plays a tumour-suppressive role in hepatocarcinogenesis. To address this, we examined the CAD transcripts in six human HCC cell lines, one liver...
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