Article
The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis.
The Journal of biological chemistry - 21 Oct 2005
Yuste Victor J, Sánchez-López Isabel, Solé Carme, Moubarak Rana S, Bayascas José R, Dolcet Xavier, Encinas Mario, Susin Santos A, Comella Joan X
Abstract excerpt
We have assessed the contribution of apoptosis-inducing factor (AIF) and inhibitor of caspase-activated DNase (ICAD) to the nuclear morphology and DNA degradation pattern in staurosporine-induced apoptosis. Expression of D117E ICAD, a mutant that is resistant to caspase cleavage at residue 117, prevented low molecular weight (LMW) DNA fragmentation, stage II nuclear morphology, and detection of terminal...
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