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Article

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease.

The Journal of biological chemistry - 2 Mar 2012

Iglesias-Guimarais Victoria, Gil-Guiñon Estel, Gabernet Gisela, García-Belinchón Mercè, Sánchez-Osuna María, Casanelles Elisenda, Comella Joan X, Yuste Victor J

Abstract excerpt

Apoptotic cell death is characterized by nuclear fragmentation and oligonucleosomal DNA degradation, mediated by the caspase-dependent specific activation of DFF40/CAD endonuclease. Here, we describe how, upon apoptotic stimuli, SK-N-AS human neuroblastoma-derived cells show apoptotic nuclear morphology without displaying concomitant internucleosomal DNA fragmentation. Cytotoxicity afforded after staurosporine...

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Identifiers

PMID: 22253444
DOI: 10.1074/jbc.M111.290718
PMCID: PMC3293563

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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