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Article

Roles of the major apoptotic nuclease-DNA fragmentation factor-in biology and disease.

Cellular and molecular life sciences : CMLS - 1 Jan 2009

Widlak P, Garrard W T

Abstract excerpt

It has now been more than ten years since the discovery of the major apoptotic nuclease, DNA fragmentation factor (DFF), also known as caspase-activated DNase (CAD). Here we review the recent literature that has uncovered new insight into DFF's regulation, and both its positive and negative roles in human disease. Cells from mice deficient in DFF still undergo apoptotic death without significant cell-autonomous...

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Source

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Identifiers

PMID: 18810317
DOI: 10.1007/s00018-008-8472-9
PMCID: PMC11131484

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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