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Article

Ricin Triggers Apoptotic Morphological Changes through Caspase-3 Cleavage of BAT3

1 Apr 2004

Abstract excerpt

Ricin, one of type II ribosomal inactivating proteins, inhibits protein biosynthesis by its RNA N-glycosidase activity. By yeast two-hybrid screening, the human BAT3 (HLA-B-associated transcript 3) was isolated as a ricin A-chain interacting protein. A canonical caspase-3 cleavage site, DEQD(1001) was found at the C-terminal region of BAT3. Ricin induced the apoptosis by activating caspase-3 and leading to the...

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PMID: 14960581
DOI: 10.1074/jbc.m307049200

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