Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity.

doi:10.1097/00007691-199712000-00007

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Article

Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity.

Therapeutic drug monitoring - 1 Dec 1997

Hedenmalm K, Sundgren M, Granberg K, Spigset O, Dahlqvist R

Abstract excerpt

The formation of morphine from codeine and ethylmorphine is mainly mediated by the polymorphic enzyme CYP2D6. The objective of this study was to investigate whether CYP2D6 poor metabolizers (PM) and CYP2D6 extensive metabolizers (EM) would respond differently during testing for opiate drugs of ab...

Topics

Adult
Analgesics, Opioid
Codeine
Cytochrome P-450 CYP2D6
Ethylmorphine
Female
Humans
Male
Metabolic Clearance Rate
Phenotype

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