Article
CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone.
Clinical pharmacology and therapeutics - 1 Nov 1993
Otton S V, Schadel M, Cheung S W, Kaplan H L, Busto U E, Sellers E M
Abstract excerpt
The contribution of cytochrome P450 2D6 (CYP2D6) to the formation of hydrocodone's active metabolite, hydromorphone, was examined in vitro and in vivo. Human liver microsomes prepared from an individual homozygous for the D6-B mutation of the CYP2D6 gene catalyzed this reaction at a negligible rate. Urinary metabolic ratios of hydrocodone/hydromorphone were highly correlated with O-demethylation ratios for...
Topics
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Female
- Humans
- Hydrocodone
- Hydromorphone
- In Vitro Techniques
- Male
- Microsomes, Liver
- Mixed Function Oxygenases
- Mutation