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Article

Influence of the CYP2D6 polymorphism and hemodialysis on codeine disposition in patients with end-stage renal disease.

European journal of clinical pharmacology - 1 Mar 2010

Molanaei Hadi, Carrero Juan Jesus, Heimbürger Olof, Nordfors Louise, Lindholm Bengt, Stenvinkel Peter, Odar-Cederlöf Ingegerd, Bertilsson Leif

Abstract excerpt

OBJECTIVE: We studied the influence of three factors on drug disposition: genetic polymorphism, impaired renal excretion of drug metabolites, and the possible elimination by hemodialysis (HD), using codeine as a model drug. METHODS: Based on the genotyping of three CYP2D6 polymorphisms in 228 HD patients, nine extensive metabolizers (EMs) and two poor metabolizers (PMs) were given a single oral dose of 50 mg...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19940985
DOI: 10.1007/s00228-009-0759-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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