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Article

Population Pharmacokinetic Quantification of CYP2D6 Activity in Codeine Metabolism in Ambulatory Surgical Patients for Model-Informed Precision Dosing.

Clinical pharmacokinetics - 1 Nov 2024

Ashraf Muhammad Waqar, Poikola Satu, Neuvonen Mikko, Kiiski Johanna I, Kontinen Vesa K, Olkkola Klaus T, Backman Janne T, Niemi Mikko, Saari Teijo I

Abstract excerpt

BACKGROUND AND OBJECTIVE: Codeine metabolism in humans is complex due to the involvement of multiple cytochrome P450 (CYP) enzymes, and has a strong genetic underpinning, which determines the levels of relevant CYP450 enzyme expression in vivo. Polymorphic CYP2D6 metabolises codeine to morphine via O-demethylation, while a strong correlation between CYP2D6 phenotype and opioidergic adverse effects of codeine is...

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Identifiers

PMID: 39441506
DOI: 10.1007/s40262-024-01433-9
PMCID: PMC11573879

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