Quantification of dextromethorphan and metabolites: a dual phenotypic marker for cytochrome P450 3A4/5 and 2D6 activity.

doi:10.1016/0378-4347(95)00431-9

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Article

Quantification of dextromethorphan and metabolites: a dual phenotypic marker for cytochrome P450 3A4/5 and 2D6 activity.

Journal of chromatography. B, Biomedical applications - 29 Mar 1996

Jones D R, Gorski J C, Hamman M A, Hall S D

Abstract excerpt

A sensitive and selective liquid chromatographic procedure using fluorimetric detection was developed to quantify dextromethorphan (DTM), 3-methoxymorphinan (3MM), dextrorphan (DT), 3-hydroxymorphinan (3OH) and two internal standards, codeine (COD) and ethylmorphine (ETM), in urine. Precision and...

Topics

Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Dextromethorphan
Humans
Mixed Function Oxygenases
Phenotype
Reproducibility of Results
Sensitivity and Specificity
Spectrometry, Fluorescence

Source

Open in PubMed

Identifiers

PMID: 8861660
DOI: 10.1016/0378-4347(95)00431-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8861660-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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