The impact of CYP2D6 polymorphisms on the pharmacokinetics of codeine and its metabolites in Mongolian Chinese subjects.

doi:10.1007/s00228-013-1573-x

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Article

The impact of CYP2D6 polymorphisms on the pharmacokinetics of codeine and its metabolites in Mongolian Chinese subjects.

European journal of clinical pharmacology - 1 Jan 2014

Wu Xiujun, Yuan Li, Zuo Jinliang, Lv Jing, Guo Tao

Abstract excerpt

PURPOSE: Codeine is an analgesic drug acting on μ-opioid receptors predominantly via its metabolite morphine formed almost exclusively by CYP2D6. Genetic polymorphisms in CYP2D6 are associated with diminished pain relief and/or severe opioid side effects. In Chinese individuals, CYP2D6*10 is the most common allele with reduced enzyme activity. In this study, we investigated the effect of this allele on the...

Topics

Administration, Oral
Adult
Alleles
Analgesics, Opioid
Area Under Curve
Asian People
Codeine
Cytochrome P-450 CYP2D6
Female
Genotype
Humans
Male
Mongolia
Morphine
Morphine Derivatives
Polymorphism, Genetic
Young Adult

Source

Open in PubMed

Identifiers

PMID: 24077935
DOI: 10.1007/s00228-013-1573-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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