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Article

Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.

British journal of clinical pharmacology - 1 May 2012

Gelston Eloise A, Coller Janet K, Lopatko Olga V, James Heather M, Schmidt Helmut, White Jason M, Somogyi Andrew A

Abstract excerpt

AIMS: To compare the O-demethylation (CYP2D6-mediated), N-demethylation (CYP3A4-mediated) and 6-glucuronidation (UGT2B4/7-mediated) metabolism of codeine between methadone- and buprenorphine-maintained CYP2D6 extensive metabolizer subjects. METHODS: Ten methadone- and eight buprenorphine-maintained subjects received a single 60 mg dose of codeine phosphate. Blood was collected at 3 h and urine over 6 h and...

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Identifiers

PMID: 22092298
DOI: 10.1111/j.1365-2125.2011.04145.x
PMCID: PMC3403206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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