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Article

Human cytolytic and interferon γ-secreting CD8 <sup>+</sup> T lymphocytes specific for <i>Mycobacterium tuberculosis</i>

6 Jan 1998

Abstract excerpt

Protective immunity to Mycobacterium tuberculosis is poorly understood, but mounting evidence, at least in animal models, implicates major histocompatibility complex class I-restricted CD8+ T cells as an essential component. By using a highly sensitive assay for single cell interferon gamma release, we screened an array of M. tuberculosis antigen-derived peptides congruent with HLA class I allele-specific motifs....

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Identifiers

PMID: 9419365
DOI: 10.1073/pnas.95.1.270

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