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Human Th1 Cell Lines Recognize the Mycobacterium tuberculosis ESAT‐6 Antigen and its Peptides in Association with Frequently Expressed HLA Class II Molecules

1 Feb 2003

Abstract excerpt

We have used a synthetic-peptide approach to map epitope regions of the Mycobacterium tuberculosis ESAT-6 antigen recognized by human T cells in relation to major histocompatibility complex (MHC) restriction. ESAT-6-specific CD4+ T-cell lines were established by stimulating peripheral blood mononuclear cells from 25 HLA-DR-typed tuberculosis patients with complete antigen in vitro. The established T-cell lines...

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PMID: 12588658
DOI: 10.1046/j.1365-3083.2003.01204.x

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