Double‐ and monofunctional CD4⁺ and CD8⁺ T‐cell responses to <i>Mycobacterium tuberculosis</i> DosR antigens and peptides in long‐term latently infected individuals

Abstract excerpt

More than 2 billion individuals are latently infected with Mycobacterium tuberculosis (Mtb). Knowledge of the key Mtb antigens and responding T-cell subsets mediating protection against Mtb is critical for developing improved tuberculosis (TB) vaccines. We previously reported that Mtb DosR-regulon-encoded antigens are recognized well by human T cells in association with control of Mtb infection. The...

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