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Article

Characterization of Human CD8+ T Cells Reactive with <i>Mycobacterium tuberculosis</i>–infected Antigen-presenting Cells

18 May 1998

Abstract excerpt

Previous studies in murine models, including those using the beta2 microglobulin knockout mouse, have suggested an important role for CD8+ T cells in host defense to Mycobacterium tuberculosis (Mtb). At present, little is understood about these cells in the human immune response to tuberculosis. This report demonstrates the existence of human Mtb-reactive CD8+ T cells. These cells are present preferentially in...

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PMID: 9584141
DOI: 10.1084/jem.187.10.1633

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