Article
Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease.
Frontiers in immunology - 1 Jan 2018
Orlando Valentina, La Manna Marco P, Goletti Delia, Palmieri Fabrizio, Lo Presti Elena, Joosten Simone A, La Mendola Carmela, Buccheri Simona, Ottenhoff Tom H M, Dieli Francesco, Caccamo Nadia
Abstract excerpt
T-cell-mediated immune responses play a fundamental role in controlling Mycobacterium tuberculosis (M. tuberculosis) infection, and traditionally, this response is thought to be mediated by Th1-type CD4+ T-cells secreting IFN-γ. While studying the function and specificity of M. tuberculosis-reactive CD4+ T-cells in more detail at the single cell level; however, we found a human CD4+ T-cell population with a naive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.