Article
Shh, Fgf4 and Hoxd gene expression in the mouse limb mutant hypodactyly.
The International journal of developmental biology - 1 Oct 1997
Robertson K E, Tickle C, Darling S M
Abstract excerpt
The semidominant mouse mutation hypodactyly (Hd), caused by a deletion within the Hoxa13 gene, results in reduced digits; heterozygotes lack digit I in the hindlimb and homozygotes have only one digit on each limb. We investigated expression of Shh and Fgf4 signaling molecules involved in digit specification in mutant limb buds. Shh and Fgf4 are expressed in the posterior part of the limb buds as normal but...
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