Article
Shh, Fgf4 and Hoxd gene expression in the mouse limb mutant hypodactyly.
The International journal of developmental biology - 1 Oct 1997
Robertson K E, Tickle C, Darling S M
Abstract excerpt
The semidominant mouse mutation hypodactyly (Hd), caused by a deletion within the Hoxa13 gene, results in reduced digits; heterozygotes lack digit I in the hindlimb and homozygotes have only one digit on each limb. We investigated expression of Shh and Fgf4 signaling molecules involved in digit s...
Topics
- Animals
- Fibroblast Growth Factor 4
- Fibroblast Growth Factors
- Gene Expression Regulation, Developmental
- Hedgehog Proteins
- Homeodomain Proteins
- In Situ Hybridization
- Limb Buds
- Limb Deformities, Congenital
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Mutation
- Proteins
- Proto-Oncogene Proteins
- RNA, Messenger
- Trans-Activators
- Transcription Factors