Article
Altered Hox expression and increased cell death distinguish Hypodactyly from Hoxa13 null mice.
The International journal of developmental biology - 1 Jul 1999
Post L C, Innis J W
Abstract excerpt
Hypodactyly (Hoxa13Hd) mice have a small deletion within the coding sequence of Hoxa13 and a limb phenotype that is more severe than that of mice with an engineered null allele of Hoxa13. We used whole-mount in situ hybridization, Nile blue sulfate staining and genetic crosses to determine the basis for the phenotypic differences between these two mutants. Expression of Hoxd13 was unaffected in Hoxa13-/- mice,...
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