Article
Impairment of Sox9 expression in limb buds of rats homozygous for hypodactyly mutation.
Folia biologica - 1 Jan 2010
Liska F, Snajdr P, Stricker S, Gosele C, Krenová D, Mundlos S, Hubner N
Abstract excerpt
Rat hypodactyly (hd) is an autosomal recessive mutation manifesting in homozygotes as reduction or loss of digits II and III. We mapped the hd allele to a short segment of chromosome 10, containing 16 genes. None of these genes has been shown to influence limb development yet. In situ hybridization showed no changes in several important patterning genes (Shh, Fgf8, Bmp2, 4, 7). However, we found that expression...
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