The molecular basis of hypodactyly (Hd): a deletion in Hoxa 13 leads to arrest of digital arch formation.

doi:10.1038/ng0796-284

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Article

The molecular basis of hypodactyly (Hd): a deletion in Hoxa 13 leads to arrest of digital arch formation.

Nature genetics - 1 Jul 1996

Mortlock D P, Post L C, Innis J W

Abstract excerpt

Hypodactyly (Hd) is a semidominant mutation in mice that maps in a genetic interval overlapping the Hoxa cluster. The profound deficiency of digital arch structures in Hd/Hd mice is consistent with a defect in a gene activated late in limb morphogenesis. We have determined the structure of the Ho...

Topics

Amino Acid Sequence
Animals
Base Sequence
Embryo, Mammalian
Gene Expression Regulation, Developmental
Homeodomain Proteins
Homozygote
Limb Deformities, Congenital
Mice
Mice, Inbred Strains
Molecular Sequence Data
Multigene Family
Mutation
Sequence Deletion
Toes

Source

Open in PubMed

Identifiers

PMID: 8673126
DOI: 10.1038/ng0796-284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8673126-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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