Article
Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice.
Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 1997
Ibnou-Zekri N, Iwamoto M, Fossati L, McConahey P J, Izui S
Abstract excerpt
The gene(s) encoded within major histocompatibility complex (MHC) act as one of the major genetic elements contributing to the susceptibility of murine systemic lupus erythematosus (SLE). We have recently demonstrated that lupus susceptibility is more closely linked to the I-E- H-2(b) haplotype than to the I-E+ H-2(d) haplotype in lupus-prone BXSB and (NZB x BXSB)F1 hybrid mice. To investigate whether the reduced...
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