Article
Contribution of H-2 and non-H-2 genes in the control of mercury-induced autoimmunity.
International immunology - 1 Oct 2000
Abedi-Valugerdi M, Möller G
Abstract excerpt
Mercury-induced autoimmunity is characterized by a T cell-dependent B cell activation (mainly of IgG1 and IgE isotypes), production of anti-nucleolar autoantibodies (ANolA) and the formation of renal IgG deposits. The autoimmunity is to a large extent controlled by genetic factors. We studied 15 different inbred mouse strains of seven H-2 (mouse MHC) genotypes to determine the importance of H-2 and non-H-2...
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