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Article

Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1999

Rozzo S J, Vyse T J, David C S, Palmer E, Izui S, Kotzin B L

Abstract excerpt

Hybrids of New Zealand Black (NZB) and New Zealand White (NZW) mice spontaneously develop a disease similar to human systemic lupus erythematosus. MHC and non-MHC genes contribute to disease susceptibility in this murine model. Multiple studies have shown that the NZW H2z locus is strongly associated with the development of lupus-like disease in these mice. The susceptibility gene(s) within H2z is not known, but...

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Share to Immunoglobulin G
Share to Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Crosses, Genetic

Share to Genes, MHC Class II

Share to Histocompatibility Antigens Class II

Share to Lupus Nephritis

Share to Mice, Inbred NZB

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PMID: 10072504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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