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Article

A novel susceptibility locus on chromosome 2 in the (New Zealand Black x New Zealand White)F1 hybrid mouse model of systemic lupus erythematosus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2002

Rahman Ziaur S M, Tin Soe-Kyaw, Buenaventura Pia-Nina L, Ho Chiu-Han, Yap Eric P H, Yong Rita Y Y, Koh Dow-Rhoon

Abstract excerpt

Systemic lupus erythematosus (SLE) is inherited as a complex polygenic trait. (New Zealand Black (NZB) x New Zealand White (NZW)) F(1) hybrid mice develop symptoms that remarkably resemble human SLE, but (NZB x PL/J)F(1) hybrids do not develop lupus. Our study was conducted using (NZW x PL/J)F(1) x NZB (BWP) mice to determine the effects of the PL/J and the NZW genome on disease. Forty-five percent of BWP female...

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Identifiers

PMID: 11884477
DOI: 10.4049/jimmunol.168.6.3042

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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