Article
The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice.
The Journal of clinical investigation - 1 Aug 1994
Merino R, Iwamoto M, Gershwin M E, Izui S
Abstract excerpt
To investigate the specific contribution of select MHC class II genes on the development of murine lupus, H-2 congenic (NZB x BXSB)F1 hybrid mice bearing either H-2b/b, H-2d/b, or H-2d/d haplotypes were generated. We compared the clinical development (autoantibody production and glomerulonephriti...
Topics
- Animals
- Autoimmunity
- Base Sequence
- Female
- Genes, MHC Class II
- Genetic Linkage
- H-2 Antigens
- Hybridization, Genetic
- Lupus Erythematosus, Systemic
- Male
- Mice
- Mice, Inbred NZB
- Molecular Sequence Data
- Mutation
- Y Chromosome