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Article

The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice.

The Journal of clinical investigation - 1 Aug 1994

Merino R, Iwamoto M, Gershwin M E, Izui S

Abstract excerpt

To investigate the specific contribution of select MHC class II genes on the development of murine lupus, H-2 congenic (NZB x BXSB)F1 hybrid mice bearing either H-2b/b, H-2d/b, or H-2d/d haplotypes were generated. We compared the clinical development (autoantibody production and glomerulonephritis) of systemic lupus erythematosus (SLE) in these three F1 hybrids in the presence or absence of the mutant gene, Yaa...

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Identifiers

PMID: 8040305
DOI: 10.1172/JCI117364
PMCID: PMC296125

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice.PMID 8040305Read ↗

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