Article
Role of mouse and human class II transgenes in susceptibility to and protection against mouse autoimmune thyroiditis.
Immunogenetics - 1 Jan 1997
Kong Y M, David C S, Lomo L C, Fuller B E, Motte R W, Giraldo A A
Abstract excerpt
Mouse experimental autoimmune thyroiditis (EAT), a model for Hashimoto's thyroiditis, is induced by immunizing with mouse thyroglobulin (MTg). To study the extent of H2A involvement in EAT, we introduced AaAb genes from susceptible k mice into resistant or intermediately susceptible strains which...
Topics
- Animals
- Disease Models, Animal
- Gene Transfer Techniques
- Genetic Predisposition to Disease
- H-2 Antigens
- HLA-DQ Antigens
- Histocompatibility Antigens Class II
- Humans
- Linkage Disequilibrium
- Mice
- Mice, Transgenic