Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dichotomous effects of complete versus partial class II major histocompatibility complex deficiency on circulating autoantibody levels in autoimmune-prone mice.

Arthritis and rheumatism - 1 Jul 2004

Stohl William, Xu Dong, Metzger Troy E, Kim Kyoung Soo, Morel Laurence, Kotzin Brian L

Abstract excerpt

OBJECTIVE: To assess the effects of altered class II major histocompatibility complex (MHCII) expression on circulating autoantibody levels in C57BL/6 (B6) mice congenic for the Sle1 (B6.Sle1 mice) or Nba2 (B6.Nba2 mice) regions. METHODS: H-2Ab(+/+) (MHCII-intact), H-2Ab(+/-) (MHCII-intermediate), and H-2Ab(-/-) (MHCII-deficient) littermate B6.Sle1 and B6.Nba2 mice were evaluated for spleen cell phenotype,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MHC Class II

Share to Histocompatibility Antigens Class II

Share to Immune Tolerance

Share to Immunoglobulin G

Share to Immunoglobulins

Share to Lupus Erythematosus, Systemic

Source

Identifiers

PMID: 15248222
DOI: 10.1002/art.20359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dichotomous effects of complete versus partial class II major histocompatibility complex deficiency on circulating autoantibody levels in autoimmune-prone mice.PMID 15248222Read ↗

Significance of MHC class II haplotypes and IgG Fc receptors in SLE.Semantic proximity Read ↗

Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity.Semantic proximity Read ↗

Deficiency of type I interferon contributes to Sle2-associated component lupus phenotypes.Semantic proximity Read ↗

Patterns of ANA+ B cells for SLE patient stratificationSemantic proximity Read ↗

Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE.Semantic proximity Read ↗

Lupus-prone B6.Nba2 male and female mice display anti-DWEYS reactivity and a neuropsychiatric phenotype.Semantic proximity Read ↗

The contribution of I-Abm12 to phenotypic and functional alterations among T-cell subsets in NZB mice.Semantic proximity Read ↗

Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD-iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3.Semantic proximity Read ↗

Immunoglobulin genes in autoimmunity.Semantic proximity Read ↗

The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.Semantic proximity Read ↗

Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease.Semantic proximity Read ↗

A lupus-suppressor BALB/c locus restricts IgG2 autoantibodies without altering intrinsic B cell-tolerance mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.