Article
Major histocompatibility complex controls susceptibility and dominant inheritance, but not the severity of the disease in mouse models of rheumatoid arthritis.
Immunogenetics - 1 Jun 2002
Adarichev Vyacheslav A, Bárdos Tamás, Christodoulou Stilliani, T Phillips Mathew, Mikecz Katalin, Glant Tibor T
Abstract excerpt
Collagen-induced arthritis (CIA) in DBA/1 and proteoglycan-induced arthritis (PGIA) in BALB/c mice are the most frequently used mouse models for studying clinical, immunological and genetic factors contributing to rheumatoid arthritis. DBA/1 ( H2(q)) mice are susceptible to CIA but resistant to PGIA, whereas BALB/c mice ( H2 (d)) are susceptible to PGIA and resistant to CIA. To gain insight into the mechanisms of...
Topics
- Animals
- Antibodies
- Arthritis, Rheumatoid
- Collagen
- Crosses, Genetic
- Genes, Dominant
- Genetic Linkage
- Genetic Predisposition to Disease
- Major Histocompatibility Complex
- Mice
- Mice, Inbred BALB C
- Mice, Inbred DBA
- Proteoglycans