Contributions of Ea(z) and Eb(z) MHC genes to lupus susceptibility in New Zealand mice.

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Article

Contributions of Ea(z) and Eb(z) MHC genes to lupus susceptibility in New Zealand mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1998

Vyse T J, Rozzo S J, Drake C G, Appel V B, Lemeur M, Izui S, Palmer E, Kotzin B L

Abstract excerpt

Unlike parental New Zealand Black (NZB) or New Zealand White (NZW) mice, (NZB x NZW)F1 mice exhibit a lupus-like disease characterized by IgG autoantibody production and severe immune complex-mediated nephritis. In studies of the genetic susceptibility to disease in this F1 model, the NZW MHC (H2z) has been strongly linked with the development of disease, and it was hypothesized that class II MHC genes,...

Topics

Animals
Autoantibodies
Genetic Linkage
Genetic Predisposition to Disease
H-2 Antigens
Histocompatibility Antigens Class II
Immunoglobulin G
Lupus Vulgaris
Mice
Mice, Inbred C57BL
Mice, Inbred NZB
Mice, Transgenic

Source

Open in PubMed

Identifiers

PMID: 9510177

Provenance

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