Article
Novel alleles of the chemokine-receptor gene CCR5.
American journal of human genetics - 1 Dec 1997
Carrington M, Kissner T, Gerrard B, Ivanov S, O'Brien S J, Dean M
Abstract excerpt
The CCR5 gene encodes a cell-surface chemokine-receptor molecule that serves as a coreceptor for macrophage-tropic strains of HIV-1. Mutations in this gene may alter expression or function of the protein product, thereby altering chemokine binding/signaling or HIV-1 infection of cells that normally express CCR5 protein. Indeed, homozygotes for a 32-bp deletion allele of CCR5 (CCR5-delta 32), which causes a...
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