Article
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.
Nature medicine - 1 Nov 1996
Huang Y, Paxton W A, Wolinsky S M, Neumann A U, Zhang L, He T, Kang S, Ceradini D, Jin Z, Yazdanbakhsh K, Kunstman K, Erickson D, Dragon E, Landau N R, Phair J, Ho D D, Koup R A
Abstract excerpt
A 32-nucleotide deletion (delta 32) within the beta-chemokine receptor 5 (CCR5) gene has been described in subjects who remain uninfected despite extensive exposure to HIV-1. This allele was found to be common in the Caucasian population with a frequency of 0.0808, but was not found in people of...
Topics
- Alleles
- Disease Progression
- Genotype
- HIV Infections
- HIV-1
- Humans
- Receptors, CCR5
- Receptors, Cytokine
- Receptors, HIV
- Risk Factors
- Sequence Deletion
- Sexually Transmitted Diseases, Viral