Article
Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases - 1 Aug 2003
Munerato Patrícia, Azevedo Maria Lúcia, Sucupira Maria Cecília Araripe, Pardini Regina, Pinto Gedson Humberto Novaes, Catroxo Márcia, Souza Inara Espinelli, Diaz Ricardo Sobhie
Abstract excerpt
Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD(4)and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors. A 32-nucleotide deletion (D32) within the b-chemokine receptor 5 gene (CCR5) has been described in subjects who...
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