Article
Novel mutations identified using a comprehensive CCR5-denaturing gradient gel electrophoresis assay.
AIDS (London, England) - 26 Jan 2001
Petersen D C, Kotze M J, Zeier M D, Grimwood A, Pretorius D, Vardas E, van Rensburg E J, Hayes V M
Abstract excerpt
BACKGROUND: Most mutations detected for the gene for CC chemokine receptor 5 (CCR5) are either relatively specific to different population groups or rarely observed in Africans. OBJECTIVES: To develop a comprehensive mutation detection assay for the entire coding region of CCR5 and to identify novel mutations that may play a role in genetic susceptibility to HIV-1 infection, within the diverse South African...
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