New Knowledge About CCR5, HIV Infection, and Disease Progression: Is "Old" Still Valuable?

Abstract excerpt

C-C chemokine receptor (CCR) 5 (CCR5) is the main HIV-1 coreceptor involved in virus entry and cell-to-cell spread during acute and chronic infections: such CCR5 and T cell tropic viruses are adapted to and replicate in CD4+ memory T cells. Polymorphisms in CCR5 regulate CCR5 expression, which, in turn, influences HIV infection acquisition and subsequent disease progression. Among these polymorphisms, a 32-bp...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Disease Progression
• Share to HIV-1
• Share to HIV Infections