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Article

Detection of new mutant sites of HIV-1 coreceptor CCR5 among Saudi populations.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Dec 2013

Abuelsaad Abdelaziz S A, Al-Ghamdi Abdullhamid S, Al-Ghamdi Ahmed N, Alakkas Eyad A, Alsulaimani Adnan A, Al-Harthi Abdulla A, Abdel-Moneim Ahmed S

Abstract excerpt

The genetic association of CCR5 with human immunodeficiency virus-1 (HIV-1) pathogenesis is well known. The HIV-1 entry into target cells is initiated by the binding of the viral envelope glycoproteins (gp120-gp41) with the cell surface receptor (CD4) and the coreceptor (CCR5), followed by fusion of the viral and cell membranes. Genetic variants of the gene-encoding HIV-1 coreceptor are implicated in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23742258
DOI: 10.1089/jir.2013.0024

Genes

CCR5

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