Article
Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences.
Human molecular genetics - 1 Jan 1999
Carrington M, Dean M, Martin M P, O'Brien S J
Abstract excerpt
The chemokine receptor gene, CCR5, has become a central theme in studies of host genetic effects on HIV-1 pathogenesis ever since the discovery that the CCR5 molecule serves as a major cell surface co-receptor for the virus. A growing number of genetic variants within the coding and 5' regulatory region of CCR5 have been identified, several of which have functional consequences for HIV-1 pathogenesis. Here we...
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