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Article

Identification of a Placental Enhancer for the Human Leptin Gene

1 Nov 1997

Abstract excerpt

Leptin is a hormone that regulates metabolic efficiency, energy expenditure, and food intake. Leptin is produced chiefly in adipose cells, but in humans, mRNA encoding leptin is also present in the placenta. Here we elucidate the basis for placental leptin production. The same promoter is used for adipose and placental transcription. An upstream enhancer functions in the JEG-3 and JAR choriocarcinoma cell lines...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 9374555
DOI: 10.1074/jbc.272.48.30583

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