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Article

FOSL2 promotes leptin gene expression in human and mouse adipocytes

13 Feb 2012

Abstract excerpt

The adipocyte-derived hormone leptin is a critical regulator of many physiological functions, ranging from satiety to immunity. Surprisingly, very little is known about the transcriptional pathways that regulate adipocyte-specific expression of leptin. Here, we report studies in which we pursued a strategy integrating BAC transgenic reporter mice, reporter assays, and chromatin state mapping to locate an...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 22326952
DOI: 10.1172/jci58431

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