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A Retroviral Promoter and a Cellular Enhancer Define a Bipartite Element Which Controls <i>env</i> ERVWE1 Placental Expression

26 Oct 2004

Abstract excerpt

The HERV-W family contains hundreds of loci diversely expressed in several physiological and pathological contexts. A unique locus termed ERVWE1 encodes an envelope glycoprotein (syncytin) involved in hominoid placental physiology. Here we show that syncytin expression is regulated by a bipartite element consisting of a cyclic AMP (cAMP)-inducible long terminal repeat (LTR) retroviral promoter adjacent to a...

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PMID: 15507602
DOI: 10.1128/jvi.78.22.12157-12168.2004

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