Article
The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
Proceedings of the National Academy of Sciences of the United States of America - 28 May 1996
Miller S G, De Vos P, Guerre-Millo M, Wong K, Hermann T, Staels B, Briggs M R, Auwerx J
Abstract excerpt
The ob gene product, leptin, apparently exclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and energy balance. ob gene expression is increased in obese rodents and regulated by feeding, insulin, and glucocorticoids, which supports the concept that ob...
Topics
- Adipocytes
- Adipose Tissue
- Animals
- Base Sequence
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- Cells, Cultured
- Consensus Sequence
- DNA Primers
- DNA-Binding Proteins
- Exons
- Gene Expression Regulation
- Humans
- Introns
- Leptin
- Molecular Sequence Data
- Nuclear Proteins
- Obesity