Allele-specific adaptation of poliovirus VP1 B-C loop variants to mutant cell receptors.

doi:10.1128/JVI.71.12.9770-9777.1997

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Article

Allele-specific adaptation of poliovirus VP1 B-C loop variants to mutant cell receptors.

Journal of virology - 1 Dec 1997

Liao S, Racaniello V

Abstract excerpt

Previous work has shown that three different mutations in domain 1 of the poliovirus receptor (Pvr), two in the predicted C'-C" ridge and one in the D-E loop, abolish binding of the P1/Mahoney strain. All three receptor defects could be suppressed by a mutation in the VP1 B-C loop of the viral ca...

Topics

Adaptation, Physiological
Alleles
Capsid
Capsid Proteins
Genetic Variation
HeLa Cells
Humans
Membrane Proteins
Models, Molecular
Mutation
Poliovirus
Receptors, Virus

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