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Article

Host-selected amino acid changes at the sialic acid binding pocket of the parvovirus capsid modulate cell binding affinity and determine virulence.

Journal of virology - 1 Feb 2006

López-Bueno Alberto, Rubio Mari-Paz, Bryant Nathan, McKenna Robert, Agbandje-McKenna Mavis, Almendral José M

Abstract excerpt

The role of receptor recognition in the emergence of virulent viruses was investigated in the infection of severe combined immunodeficient (SCID) mice by the apathogenic prototype strain of the parvovirus minute virus of mice (MVMp). Genetic analysis of isolated MVMp viral clones (n = 48) emerging in mice, including lethal variants, showed only one of three single changes (V325M, I362S, or K368R) in the common...

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Identifiers

PMID: 16415031
DOI: 10.1128/JVI.80.3.1563-1573.2006
PMCID: PMC1346950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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