Article
Cell culture adaptation mutations in foot-and-mouth disease virus serotype A capsid proteins: implications for receptor interactions.
The Journal of general virology - 1 Mar 2015
Mohapatra Jajati K, Pandey Laxmi K, Rai Devendra K, Das Biswajit, Rodriguez Luis L, Rout Manoranjan, Subramaniam Saravanan, Sanyal Aniket, Rieder Elizabeth, Pattnaik Bramhadev
Abstract excerpt
In this study we describe the adaptive changes fixed on the capsid of several foot-and-mouth disease virus serotype A strains during propagation in cell monolayers. Viruses passaged extensively in three cell lines (BHK-21, LFBK and IB-RS-2) consistently gained positively charged amino acids in the putative heparin-sulfate-binding pocket (VP2 βE-βF loop, VP1 C-terminus and VP3 β-B knob) surrounding the fivefold...
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