Article
Mouse adaptation determinants of poliovirus type 1 enhance viral uncoating.
Journal of virology - 1 Jan 1996
Couderc T, Delpeyroux F, Le Blay H, Blondel B
Abstract excerpt
Most poliovirus (PV) strains, such as PV type 1/Mahoney, cannot infect the mouse central nervous system. We previously identified two determinants of mouse adaptation of PV type 1/Mahoney at positions 22 and 31 of the viral capsid proteins VP1 and VP2, respectively (T. Couderc, J. Hogle, H. Le Bl...
Topics
- Adaptation, Physiological
- Animals
- Binding Sites
- Capsid
- Capsid Proteins
- Defective Viruses
- HeLa Cells
- Hot Temperature
- Humans
- Mice
- Mutation
- Poliovirus
- RNA, Viral
- Tumor Cells, Cultured
- Virus Assembly