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Article

Mouse adaptation determinants of poliovirus type 1 enhance viral uncoating.

Journal of virology - 1 Jan 1996

Couderc T, Delpeyroux F, Le Blay H, Blondel B

Abstract excerpt

Most poliovirus (PV) strains, such as PV type 1/Mahoney, cannot infect the mouse central nervous system. We previously identified two determinants of mouse adaptation of PV type 1/Mahoney at positions 22 and 31 of the viral capsid proteins VP1 and VP2, respectively (T. Couderc, J. Hogle, H. Le Blay, F. Horaud, and B. Blondel, J. Virol. 67:3808-3817, 1993). These residues are located on the interior surface of the...

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Identifiers

PMID: 8523541
DOI: 10.1128/JVI.70.1.305-312.1996
PMCID: PMC189818

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