Article
Canyon rim residues, including antigenic determinants, modulate serotype-specific binding of polioviruses to mutants of the poliovirus receptor.
Virology - 20 Dec 1995
Harber J, Bernhardt G, Lu H H, Sgro J Y, Wimmer E
Abstract excerpt
Several mouse cell lines expressing hybrid human poliovirus receptors (hPVRs) bearing mutations in the first immunoglobulin-like domain were previously characterized for their defective binding and replication of poliovirus type 1 Mahoney (G. Bernhardt, J. Harber, A. Zibert, M. DeCrombrugghe, and E. Wimmer, Virology, 203, 344-356, 1994). Here we report that these mutant hPVRs were utilized to explore differences...
Topics
- Animals
- Base Sequence
- Capsid
- Cell Line
- DNA, Viral
- Defective Viruses
- Epitopes
- HeLa Cells
- Humans
- Mice
- Molecular Sequence Data
- Mutation