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Article

Soluble receptor-resistant poliovirus mutants identify surface and internal capsid residues that control interaction with the cell receptor.

The EMBO journal - 15 Dec 1994

Colston E, Racaniello V R

Abstract excerpt

Poliovirus initiates infection by binding to its cell receptor and undergoing a receptor-mediated conformational alteration. To identify capsid residues that control these interactions, we have isolated and characterized poliovirus mutants that are resistant to neutralization by a soluble form of...

Topics

Capsid
Capsid Proteins
Cloning, Molecular
HeLa Cells
Humans
Membrane Proteins
Models, Molecular
Mutation
Poliovirus
Protein Binding
Receptors, Virus
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Selection, Genetic

Sequence Analysis, DNA

Solubility

Structure-Activity Relationship

Source

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Identifiers

PMID: 7813425
DOI: 10.1002/j.1460-2075.1994.tb06930.x
PMCID: PMC395560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7813425-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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