Adaptation of Theiler's virus to L929 cells: mutations in the putative receptor binding site on the capsid map to neutralization sites and modulate viral persistence.

doi:10.1006/viro.1998.9134

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Article

Adaptation of Theiler's virus to L929 cells: mutations in the putative receptor binding site on the capsid map to neutralization sites and modulate viral persistence.

Virology - 10 May 1998

Jnaoui K, Michiels T

Abstract excerpt

Persistent strains of Theiler's virus, a murine picornavirus, produce a life-long infection of the central nervous system of the mouse and induce a chronic demyelinating disease. Strain DA1, a molecular clone of such a persistent strain, produces a prominent cytopathic effect in BHK-21 cells but...

Topics

Adaptation, Physiological
Animals
Capsid
Cell Line
Cricetinae
Cytopathogenic Effect, Viral
Female
Mice
Mutation
Neutralization Tests
Poliomyelitis
Receptors, Virus
Theilovirus
Virulence

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