Article
The poliovirus receptor: identification of domains and amino acid residues critical for virus binding.
Virology - 1 Sept 1994
Bernhardt G, Harber J, Zibert A, deCrombrugghe M, Wimmer E
Abstract excerpt
The N-terminal domain 1 of the human poliovirus receptor (hPVR), a three-domain, immunoglobulin-like molecule, was previously shown to be necessary and sufficient to confer poliovirus (PV) susceptibility to mouse cells. However, studies with truncated versions of hPVR suggested that the C-termina...
Topics
- Animals
- Antibodies, Monoclonal
- Binding Sites
- Cell Adhesion Molecules
- Intercellular Adhesion Molecule-1
- Mice
- Models, Molecular
- Mutation
- Poliovirus
- Receptors, Virus
- Structure-Activity Relationship