Article
Reduction in fibronectin expression and alteration in cell morphology are coincident in NIH3T3 cells expressing a mutant E2F1 transcription factor.
Experimental cell research - 1 Nov 1997
Jordan-Sciutto K L, Logan T J, Norton P A, Derfoul A, Dodge G R, Hall D J
Abstract excerpt
Fibronectin within the extracellular matrix plays a role in cell attachment, spreading, and shape, while it also affects aspects of cell proliferation. Transcription factors such as E2F1 are also known to regulate cell shape and cell proliferation. Yet, to date no linkage has been established between fibronectin expression and E2F1. We show here that cells constitutively expressing a mutant E2F1 protein (E2F1d87)...
Topics
- 3T3 Cells
- Animals
- Carrier Proteins
- Cell Cycle Proteins
- Cell Size
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Fibronectins
- Gene Expression Regulation
- Mice
- Mutation
- Promoter Regions, Genetic